What are the best longevity supplements to start with?

Most people start with vitamin D3, omega-3, magnesium, and creatine. Then, they add ingredients for a specific goal, such as NR or NMN for NAD+ levels, CoQ10 for cellular energy or curcumin for inflammation.

Are anti-aging supplements different for men and women?

The core ingredients are the same for both: NAD+ precursors, CoQ10, omega-3 and antioxidants like glutathione. Women after menopause often focus more on vitamin D3 and K2, and men over 40 often focus on CoQ10 and creatine.

Can you take several anti-aging supplements together?

Many people combine them, and some pairs are often taken together, like NR with resveratrol or vitamin D3 with K2. Check that you’re not doubling up on the same ingredient across products, and talk to your doctor if you take medications.

How long do longevity supplements take to work?

Most studies run 8-12 weeks before measuring results. Blood levels change faster: NAD+ rises within a few weeks of taking NR, and omega-3 levels reach a steady state in about 3-4 months. Many benefits of healthy aging supplements are long-term and won’t show up as noticeable day-to-day changes.

Longevity & Anti-Aging Supplements

130 products

Shop longevity and anti-aging supplements from Thorne, Tru Niagen, Codeage, XYMOGEN and Nordic Naturals for cellular longevity, telomere and DNA health, mitochondrial energy, brain neuroprotection, antioxidant protection and inflammation support.

What Are Longevity Supplements?

Anti-aging and longevity supplements are vitamins and nutrients taken to support the body as it ages. Most of them work on processes that slow down over time: NMN and NR raise NAD+ levels that cells need for energy and DNA repair, CoQ10 supports energy production in mitochondria, quercetin is studied for its effect on senescent cells, and glutathione, resveratrol and astaxanthin protect cells from oxidative stress. Collagen and vitamin C are often added for skin, since vitamin C helps the body produce collagen.

Longevity Supplements by Goal

Telomere & DNA. Choose from vitamin D3 and D3 + K2, omega-3, B vitamins, plus magnesium and zinc.
Cellular Longevity. NAD+ precursors are the core of this collection, including nicotinamide riboside and liposomal NMN. Quercetin and resveratrol are common additions.
Mitochondrial Energy. CoQ10 in ubiquinone and ubiquinol forms is the usual first choice for cellular energy. Creatine and magnesium malate are also available.
Brain Clarity & Neuroprotection. Look for phosphatidylserine, magnesium L-threonate (Magtein) and lion’s mane mushroom extracts.
Antioxidants. Glutathione comes in liposomal and S-acetyl forms that absorb better than the standard one. NAC and astaxanthin round out the collection.
Anti-inflammation. Fish oil and curcumin are the usual first choice here, since both have the most human research on inflammatory markers. Boswellia and butyrate are common second-step additions.

Best Longevity Supplements Compared

	Tru Niagen, Niagen NR Age Better, 300 mg, 90 Vegicaps	XYMOGEN, CoQmax Ubiquinol, 200 mg, 60 Softgels	Seeking Health, Vitamin D3 + K2, 125 mcg (5,000 IU) / 100 mcg, 60 Caps	Momentous, Magnesium L-Threonate Sleep & Cognitive Support, 145 mg, 90 Caps	Codeage, Liposomal Setria Glutathione, 500 mg, 60 Vegicaps	Thorne, Curcumin Phytosome NSF Certified for Sport, 1000 mg, 120 Caps
Best For	Cellular Longevity	Mitochondrial Energy	Telomere & DNA	Brain Clarity & Neuroprotection	Antioxidants	Anti-inflammation
Key Ingredient	NR (Nicotinamide riboside)	CoQ10 as ubiquinol	Vitamin D3 + K2	Magnesium L-threonate	Setria L-glutathione	Curcumin phytosome
Form	Capsules	Softgels	Capsules	Capsules	Capsules	Capsules
Servings per Container	90	60	60	30	30	60
Price	$127.99	$82.99	$25.00	$49.99	$39.99	$68.00

FAQs

What are the best longevity supplements to start with?: Most people start with vitamin D3, omega-3, magnesium, and creatine. Then, they add ingredients for a specific goal, such as NR or NMN for NAD+ levels, CoQ10 for cellular energy or curcumin for inflammation.
Are anti-aging supplements different for men and women?: The core ingredients are the same for both: NAD+ precursors, CoQ10, omega-3 and antioxidants like glutathione. Women after menopause often focus more on vitamin D3 and K2, and men over 40 often focus on CoQ10 and creatine.
Can you take several anti-aging supplements together?: Many people combine them, and some pairs are often taken together, like NR with resveratrol or vitamin D3 with K2. Check that you’re not doubling up on the same ingredient across products, and talk to your doctor if you take medications.
How long do longevity supplements take to work?: Most studies run 8-12 weeks before measuring results. Blood levels change faster: NAD+ rises within a few weeks of taking NR, and omega-3 levels reach a steady state in about 3-4 months. Many benefits of healthy aging supplements are long-term and won’t show up as noticeable day-to-day changes.

Return to Products

Longevity & Anti-Aging Supplements

Ancient Nutrition, Active Peptides Magnesium Complex, 90 Caps

Ancient Nutrition, Ancient Nutrients Magnesium + Vitamin D, 300 mg / 25 mcg (1000 IU), 90 Caps

Ancient Nutrition, Creatine + Collagen + Electrolytes, Lemon, 5 g, 9.6 oz

Ancient Nutrition, Multi Protein Animal Based + Creatine, Dark Chocolate, 26 g / 5 g, 1.37 lb

Ancient Nutrition, Vitamin D3 + K2, 125 mcg (5000 IU) / 90 mcg, 60 Caps

BodyBio, Balance Oil Omega-6 + Omega-3, 1250 mg / 310 mg, 16 fl oz

BodyBio, Balance Oil Omega-6 + Omega-3, 1400 mg / 350 mg, 180 Softgels

BodyBio, Calcium Magnesium Butyrate Postbiotic Gut Health, 1200 mg, 100 Caps

BodyBio, Liposomal Glutathione, 250 mg, 60 Caps

BodyBio, Liposomal Vitamin C, 1000 mg, 60 Caps

BodyBio, PC Liposomal Phospholipid Complex Liquid, 1300 mg, 4 fl oz

BodyBio, PC Liposomal Phospholipid Complex, 1300 mg, 60 Softgels

BodyBio, Sodium Butyrate Postbiotic Gut Health, 1200 mg, 100 Caps

BodyBio, TUDCA Liver Health, 500 mg, 60 Caps

Codeage, Liposomal Apigenin, 50 mg, 90 Vegicaps

Codeage, Liposomal Magnesium Glycinate, 360 mg, 240 Vegicaps

Codeage, Liposomal NAD ULTRA Sport with Vitamin B12, 500 mg / 250 mcg, 90 Vegicaps

Codeage, Liposomal NAD, 500 mg, 60 Vegicaps

Codeage, Liposomal NMN Platinum with Quercetin, 500 mg / 250 mg, 90 Vegicaps

Codeage, Liposomal Setria Glutathione, 500 mg, 60 Vegicaps

Codeage, Liposomal Vitamin C with Bioflavonoids, 1500 mg / 50 mg, 180 Vegicaps

Codeage, Magtein Liposomal Magnesium L-Threonate, 144 mg, 90 Vegicaps

Codeage, Meditate Vitamins with CognatiQ, GABA & Ashwagandha, 60 Vegicaps

Codeage, Methylfolate B Complex, 120 Vegicaps

What Are Longevity Supplements?

Longevity Supplements by Goal

Best Longevity Supplements Compared

FAQs