What’s the difference between probiotics and prebiotics?

Probiotics contain live microorganisms, including beneficial bacteria and certain yeasts. Prebiotics feed bacteria already living in your gut. Some supplements combine both, and these are called synbiotics.

How long do gut health supplements take to work?

It depends on the supplement and why you're taking it. Digestive enzymes work on the meal you take them with, while changes from fiber or probiotics may take longer to notice. Follow the product's directions and give yourself time to assess how you feel.

Can gut health supplements cause bloating?

Yes. Fiber and prebiotics can cause gas, especially when you add too much too quickly. Starting with a small amount and increasing gradually may make the adjustment easier.

Do probiotics need to be refrigerated?

Some do, and others are made to stay stable at room temperature. Check the storage instructions on the label.

Do digestive enzymes help with every meal?

Different enzymes break down different food components. Lactase, for example, breaks down lactose in dairy, while lipase breaks down fat. The right choice depends on what's in your meal and what you have difficulty digesting.

What does “leaky gut support” mean on a supplement label?

The phrase generally refers to products intended to support the intestinal lining and its barrier function. Common ingredients include L-glutamine and zinc carnosine. The label alone doesn't mean a product has been shown to repair the gut lining or address the cause of digestive symptoms.

Gut Health Supplements

174 products

Shop gut health supplements from Thorne, Garden of Life, Microbiome Labs, Pendulum, Ritual and other trusted brands: probiotics, prebiotics and fiber, digestive enzymes, amino acids, butyrate and bile support. They help with everyday digestive problems like bloating after meals, constipation, heaviness after fatty food and gut balance after antibiotics.

What Are Gut Health Supplements?

Gut health supplements are products that support the digestive tract from the stomach to the colon: how food breaks down, how often you go, what lives in your gut, and how the gut lining holds up. On this page you’ll find them grouped by goal, so you can start with what bothers you most:

Fill Nutrient Gaps: vitamin D, magnesium, B vitamins, omega-3s and multivitamins for nutrients that often run low when meals are irregular.
Digestion Support: digestive enzymes for protein, fat, carbs and dairy, plus fiber for smoother digestion.
Stomach Acid & Bile Relief: bile and liver support with TUDCA and artichoke leaf extract, plus a gut formula with L-glutamine and DGL.
Gut Microbiome Support: probiotics, synbiotics and postbiotics like butyrate for the bacteria in your gut.
Fiber & Regularity Support: soluble fibers such as psyllium husk, acacia gum and PHGG for steady bowel habits.
Bloating & Gas Support: enzymes, probiotic strains and herbs for a tight feeling after eating.
Gut Lining & Leaky Gut Support: L-glutamine, immunoglobulins, collagen, bone broth and butyrate for the intestinal barrier.
Constipation Relief: magnesium citrate and oxide, bulk-forming fiber and other options for occasional constipation.
Daily Greens & Whole Food: multivitamins, vitamin C and zinc made from whole foods.
Special Diet Support: plant-based protein, algal omega-3, B vitamins and iron for plant-based and restricted diets.

Gut Health Supplements Compared by Goal

	Microbiome Labs, MegaSporeBiotic Spore-Based Probiotic, 4 billion CFU, 60 Caps	Ritual, Synbiotic+, Mint, 30 Vegicaps	Pendulum, Akkermansia with Chicory Inulin, 100 million AFU / 276 mg, 30 Caps	Thorne, FiberMend Prebiotic Fiber, 8 g, 11.6 oz	BodyBio, TUDCA Liver Health, 500 mg, 60 Caps	Seeking Health, DAO Enzyme, 30000 HDU, 90 Caps
Best For	Gut Microbiome Support	Gut Microbiome Support, Bloating & Gas Support	Gut Microbiome Support, Gut Lining & Leaky Gut Support	Fiber & Regularity Support	Stomach Acid & Bile Relief	Digestion Support
Type	Probiotic	Synbiotic	Probiotic	Prebiotic fiber	Bile acid	Digestive enzyme
Form	Capsules	Capsules	Capsules	Powder	Capsules	Capsules
Servings per Container	30	30	30	30	30	90
Price	$66.25	$54.00	$75.00	$45.00	$59.99	$90.00

FAQs

What’s the difference between probiotics and prebiotics?: Probiotics contain live microorganisms, including beneficial bacteria and certain yeasts. Prebiotics feed bacteria already living in your gut. Some supplements combine both, and these are called synbiotics.
How long do gut health supplements take to work?: It depends on the supplement and why you're taking it. Digestive enzymes work on the meal you take them with, while changes from fiber or probiotics may take longer to notice. Follow the product's directions and give yourself time to assess how you feel.
Can gut health supplements cause bloating?: Yes. Fiber and prebiotics can cause gas, especially when you add too much too quickly. Starting with a small amount and increasing gradually may make the adjustment easier.
Do probiotics need to be refrigerated?: Some do, and others are made to stay stable at room temperature. Check the storage instructions on the label.
Do digestive enzymes help with every meal?: Different enzymes break down different food components. Lactase, for example, breaks down lactose in dairy, while lipase breaks down fat. The right choice depends on what's in your meal and what you have difficulty digesting.
What does “leaky gut support” mean on a supplement label?: The phrase generally refers to products intended to support the intestinal lining and its barrier function. Common ingredients include L-glutamine and zinc carnosine. The label alone doesn't mean a product has been shown to repair the gut lining or address the cause of digestive symptoms.

Return to Products

Gut Health Supplements

Ancient Nutrition, Active Peptides Magnesium Complex, 90 Caps

Ancient Nutrition, Ancient Nutrients Magnesium + Vitamin D, 300 mg / 25 mcg (1000 IU), 90 Caps

Ancient Nutrition, Bone Broth Protein, Chocolate, 20 g, 1.1 lb

Ancient Nutrition, Bone Broth Protein, Pure, 20 g, 15.07 oz

Ancient Nutrition, Bone Broth Protein, Vanilla, 20 g, 1.1 lb

Ancient Nutrition, Multi Collagen Protein Beauty Within, Guava Passionfruit, 20 g, 1.14 lb

Ancient Nutrition, Multi Collagen Protein, Chocolate, 20 g, 1.04 lb

Ancient Nutrition, Multi Collagen Protein, Unflavored, 20 g, 1 lb

Ancient Nutrition, Multi Collagen Protein, Vanilla, 20 g, 1.04 lb

Ancient Nutrition, Multi Collagen, 90 Caps

Ancient Nutrition, Multi Protein Animal Based + Creatine, Dark Chocolate, 26 g / 5 g, 1.37 lb

Ancient Nutrition, Multivitamin Women’s 40+, 90 Caps

Ancient Nutrition, SBO Probiotics Gut Restore, 25 billion CFU, 60 Caps

Ancient Nutrition, SBO Probiotics Ultimate, 50 billion CFU, 60 Caps

Ancient Nutrition, Vitamin D3 + K2, 125 mcg (5000 IU) / 90 mcg, 60 Caps

Ancient Nutrition, Women’s Vitality, 180 Caps

BodyBio, Balance Oil Omega-6 + Omega-3, 1250 mg / 310 mg, 16 fl oz

BodyBio, Balance Oil Omega-6 + Omega-3, 1400 mg / 350 mg, 180 Softgels

BodyBio, Calcium Magnesium Butyrate Postbiotic Gut Health, 1200 mg, 100 Caps

BodyBio, Sodium Butyrate Postbiotic Gut Health, 1200 mg, 100 Caps

BodyBio, TUDCA Liver Health, 500 mg, 60 Caps

Codeage, Fermented Digestive Enzymes & Botanicals, 90 Vegicaps

Codeage, Full Spectrum Binder, 90 Vegicaps

Codeage, GLP-1 Probiotic, 500 Million AFU, 90 Vegicaps

What Are Gut Health Supplements?

Gut Health Supplements Compared by Goal

FAQs